Search results for "Chronic skin ulcers"
showing 2 items of 2 documents
Prolidase deficiency in two dermatological patients in western Sicily
2020
Prolidase deficiency is a rare disorder inherited through an autosomal recessive gene. The hallmark of the disorder are iminodipeptiduria, chronic skin ulcers, recurring infections, mental retardation and characteristic facial appearance, although prolidase deficiency can occur with no clinical manifestation. The primary biological function of the enzyme involves the metabolism of collagen degradation products and the recycling of proline for collagen resynthesis. We describe two patients with prolidase deficiency and review the different clinical manifestations suggesting the pathogenetic mechanism through few hypotheses.
Polarization-sensitive hyperspectral imaging of human skin: From system design to clinical validation (Conference Presentation)
2020
We present the development and validation of a new approach for quantitative functional imaging of human skin based on the machine learning technique for the analysis of the hyperspectral skin images. The considered skin parameters include blood volume fraction, blood oxygenation, melanin content, and the epidermal layer thickness. Additionally, the degree of residual polarization of the reflected light has been analyzed. The validity of the approach has been confirmed by the initial preclinical tests with the tissue-mimicking phantoms, functional in-vivo skin tests, and pilot clinical study of type II diabetic patients. The proposed technique has great potential to be implemented in clinic…